Dietrich M. Egli, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Developmental Cell Biology (in Pediatrics)

Dieter Egli obtained his PhD degree from the University of Zurich, Switzerland, with Walter Schaffner, and trained as a postdoctoral fellow at Harvard University with Kevin Eggan. He joined the New York Stem Cell Foundation Research Institute as a Research Fellow, conducting work on somatic cell reprogramming in human eggs. He is now the Maimonides Assistant Professor of Developmental Cell Biology at Columbia University, with appointments at the Department of Pediatrics and Obstetrics and Gynecology.

Dr. Egli’s group studies a broad range of topics, which are connected at the level of the pluripotent stem cell, and combine basic research with therapeutic goals. The study of stem cell derived human beta cells enables the study of genes and pathways involved in beta cell failure, while also providing a source of cells that will likely be useful for cell replacement. Through grafting of human stem cell derived beta cells into animal models of diabetes we can study human genotypes in a physiologically relevant environment. In our studies to reprogram somatic cells of a diabetes patient to pluripotent stem cells, we discovered that this transition is associated with replication-dependent genetic instability. Similarly, we have seen that genetic instability is frequent during early human embryonic development, and associated with developmental arrest. A central goal of our group is to better understand the differences in the duplication of the DNA between different cell types, how these differences affect genetic stability, and to understand their functional relevance. A novel concept emerging from these studies is that cell-type specific DNA replication provides a quality control system for cell proliferation, limiting the number of cellular states compatible with the duplication of the DNA. There are numerous exciting project opportunities emerging from this concept, including on stem cell models of pregnancy loss. Other projects conducted in the Egli lab are on mitochondrial replacement and on haploid pluripotent stem cells.

Languages

  • French
  • German

Gender

  • Male

Credentials & Experience

Education & Training

  • PhD, 2003 Molecular Biology, University of Zurich (Switzerland)

Honors & Awards

1994    Awarded membership in the ‘Schweizerische Studienstiftung’, a foundation that promotes outstanding students.    

2000    Excellency award for Masters

2003    Excellency award for PhD thesis

2011    Time magazine ‘Medical Breakthrough of the Year’

2011    Time magazine ‘People who mattered in 2011’

2012-2017       NYSCF-Robertson Investigator

2015    Maimonides Assistant Professor

2016    Harold and Golden Lamport Award for Excellence in Clinical Science Research

Research

Grants

NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

Dec 1 1996 - Mar 31 2021

GENETIC SCREENING USING HUMAN HAPLOID EMBRYONIC STEM CELLS (Private)

Sep 1 2016 - Aug 31 2020

MICE WITH AUTOLOGOUS HUMAN T1D-DERIVED IMMUNE SYSTEMS AND IPSC-DERIVED BETA CELL (Federal Gov)

Sep 25 2014 - Jun 30 2019

IMMUNE RESPONSE TO IPSC-DERIVED BETA CELLS IN TYPE 1 DIABETES (Federal Gov)

Apr 1 2015 - Mar 31 2019

MONOGENETIC FORMS OF DIABETES AS A TARGET FOR STEM CELL REPLACEMENT? (Private)

Jan 1 2016 - Dec 31 2018

MITOCHONDRIAL REPLACEMENT IN HUMAN OOCYTES (Private)

Jul 1 2016 - Jun 30 2018

NEW YORK STEM CELL FOUNDATION ROBERTSON INVESTIGATOR (Private)

Jan 1 2017 - Dec 31 2017

HELMSLEY TRUST DIABETES CELL REPOSITORY (Private)

Jan 1 2015 - Dec 31 2017

SANOFI INNOVATION AWARDS PROGRAM (Private)

Dec 20 2016 - Dec 19 2017

CLINICAL INVESTIGATION OF EFFICACY OF TAUROURODEOXYCHOLIC ACID (TUDCA) TO ENHANCE PANCREATIC BETA CELL SURVIVAL IN TYPE 1 DIABETES BY REDUCING ER STRESS (Private)

Oct 1 2014 - Sep 30 2017

TO FUNCTIONALLY EVALUATE POSSIBLE DISEASE-CAUSING VARIANTS IDENTIFIED IN WES/WGS TO DETERMINE PATHOGENICITY OF RARE VARIANTS AND DISEASE MECHANISM. (Private)

Jul 1 2014 - Jun 30 2016

THE ROLE OF ENDOPLASMIC RETICULUM STRESS IN DIABETIC BETA CELL FAILURE (NY State Gov)

Jun 1 2014 - May 31 2016

NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

Jun 10 2011 - Dec 31 2014