Lei Ding, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Rehabilitation and Regenerative Medicine
  • Assistant Professor of Microbiology & Immunology

B. S. Peking University, Beijing, China, 2001

Ph.D. University of Colorado, Boulder, 2001-2006

Postdoctroal Fellow University of Michigan, Ann Arbor, 2007-2011

Postdoctoral Fellow UT Southwestern, 2011-2013

Assistant Professor, Columbia University Medical Center, 2013-present

Credentials & Experience

Honors & Awards

Helen Hay Whitney Foundatation Postdoctoral Fellowship 2008-2011

Cancer Research Institute Postdoctoral Fellowship (declined) 2008

Rita Allen Foundation Scholar 2014-

Schaefer Scholar 2017

Irma Hirschl Research Award 2017-2021

Research

Hematopoietic stem cells (HSCs) are rare self-renewing cells that can generate the whole blood system throughout life. They are widely used in clinics to treat a number of hematopoietic disorders. But the rareness of HSCs has been hindering the safer and broader use of HSCs in clinics. Each year, thousands of lives can not be saved through HSC transplantation due to the insufficient supply of HSCs. Despite decades of efforts, no culture systems are available to maintain and expand HSCs in vitro. Yet, in vivo, HSCs robustly self-renew. We believe that understanding the microenvironmental niche in vivo is the key to solve this unmet medical challenge. In the lab, we are focusing elucidating the niche mechanisms that maintain HSCs in homeostasis and expand HSCs during development using genetically modified mouse models. As the bone marrow niche is increasingly appreciated as an important contributor to hematopoietic diseases, we also study the niche mechanisms in hematopoietic malignancies. 

Research Interests

  • hematopoietic stem cell biology
  • extrinsic regulation of stem cells
  • hematopoietic malignancies

Grants

THE ROLE OF LOCAL AND SYSTEMIC THROMBOPOIETIN IN HEMATOPOIETICSTEM CELL REGULATION (Private)

Jan 1 2017 - Dec 31 2021

LOCAL AND SYSTEMIC REGULATION OF HEMATOPOIETIC STEM CELLS BY THROMBOPOIETIN (Federal Gov)

Jul 1 2017 - Jun 30 2021

IMMUNE PRIVILEGE OF THE HEMATOPOIEITIC STEM CELL NICHE (Federal Gov)

Jul 1 2016 - Mar 31 2021

REGULATION OF HEMATOPOIETIC STEM CELLS AND LEUKEMIA STEM CELLS BY THROMBOPOIETIN (Federal Gov)

Apr 1 2016 - Mar 31 2021

UNDERSTANDING THE FETAL LIVER HEMATOPOIETIC STEM CELL NICHE (Private)

Sep 1 2014 - Aug 30 2019

MICE WITH AUTOLOGOUS HUMAN T1D-DERIVED IMMUNE SYSTEMS AND IPSC-DERIVED BETA CELL (Federal Gov)

Sep 25 2014 - Jun 30 2019

HEMATOPOIETIC STEM CELL NICHE IN MYELOFIBROSIS (Private)

Oct 1 2014 - Sep 30 2015